Bone mineral density
Has been studied as a source of calcium, protein and vitamin K2. Trials of menaquinone supplements on bone density report mixed results at doses far above what cheese supplies, and no trial has tested aged cheese itself.
What may be going on: Menaquinones are cofactors for the carboxylation of osteocalcin, a bone matrix protein.
Limited evidence. Early human work, or mostly lab and animal research.
3 sources
- Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.(opens in a new tab)
Meta-analysis · Frontiers in public health · 2022 · PMID 36033779
- Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.(opens in a new tab)
Randomised controlled trial · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013 · PMID 23525894
- Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.(opens in a new tab)
Randomised controlled trial · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2000 · PMID 11180916
Deep research mode adds each paper’s own conclusion and stated limitations.