Blood lipid profile
Research suggests that regular intake of oily fish or its long-chain omega-3 fatty acids lowers blood triglycerides. This is one of the most consistently replicated effects in nutrition, with a clear dose relationship and the largest effects in people whose triglycerides start high.
What may be going on: EPA and DHA reduce hepatic VLDL triglyceride assembly and secretion and increase lipoprotein lipase-mediated clearance.
Strong evidence. Consistent findings across multiple good-quality human studies.
3 sources
- Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.(opens in a new tab)
Meta-analysis · Journal of the American Heart Association · 2023 · PMID 37264945
- Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.(opens in a new tab)
Meta-analysis · The Cochrane database of systematic reviews · 2020 · PMID 32114706
- Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.(opens in a new tab)
Meta-analysis · The Cochrane database of systematic reviews · 2018 · PMID 30019766
Deep research mode adds each paper’s own conclusion and stated limitations.