Endothelial function
Evidence is limited. Trials of citrus flavanones and orange juice report small improvements in measures of vascular function, and hesperidin is the compound usually credited. Almost none of that work used mandarins specifically, so the read-across to this fruit is an assumption.
Limited evidence. Early human work, or mostly lab and animal research.
4 sources
- Endothelial and Cardiovascular Effects of Naringin: A Systematic Review.(opens in a new tab)
Systematic review · Nutrients · 2025 · PMID 40871686
- Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review.(opens in a new tab)
Systematic review · Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016 · PMID 27079631
- The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose-response meta-analysis of randomized clinical trials.(opens in a new tab)
Meta-analysis · Phytotherapy research : PTR · 2024 · PMID 38561995
- Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials.(opens in a new tab)
Systematic review · Nutrition reviews · 2019 · PMID 31271436
Deep research mode adds each paper’s own conclusion and stated limitations.