Gut microbiome
Research suggests fungal beta-glucans and chitin reach the colon largely intact and are fermented there. Human data on shiitake specifically is early and the consequences of the microbial shifts are unclear.
Limited evidence. Early human work, or mostly lab and animal research.
2 sources
- Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes.(opens in a new tab)
Randomised controlled trial · European journal of nutrition · 2021 · PMID 33580297
- Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial.(opens in a new tab)
Randomised controlled trial · Nutrients · 2021 · PMID 34444843
Deep research mode adds each paper’s own conclusion and stated limitations.