Endothelial function
Evidence is limited for an effect on vascular function. A handful of trials report improved flow-mediated dilation after citrus flavanones, usually at doses higher than a single glass of juice supplies.
Limited evidence. Early human work, or mostly lab and animal research.
4 sources
- Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review.(opens in a new tab)
Systematic review · Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016 · PMID 27079631
- Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials.(opens in a new tab)
Systematic review · Nutrition reviews · 2019 · PMID 31271436
- Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals.(opens in a new tab)
Randomised controlled trial · The American journal of clinical nutrition · 2016 · PMID 27797708
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial.(opens in a new tab)
Randomised controlled trial · The journal of nutrition, health & aging · 2022 · PMID 36156675
Deep research mode adds each paper’s own conclusion and stated limitations.