Healthy blood pressure
A few small Japanese trials report modest reductions in blood pressure with daily wakame, and peptides from the seaweed inhibit angiotensin-converting enzyme in laboratory testing. The trials are small, largely from one research tradition, and have not been replicated elsewhere.
What may be going on: Peptides released from wakame protein inhibit angiotensin-converting enzyme in vitro, the same target as a common class of blood pressure drug.
Limited evidence. Early human work, or mostly lab and animal research.
4 sources
- Edible Algae Reduce Blood Pressure in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.(opens in a new tab)
Meta-analysis · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025 · PMID 40726022
- The Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action.(opens in a new tab)
Systematic review · Nutrients · 2022 · PMID 35893900
- Effects of spirulina and wakame consumption on intestinal cholesterol absorption and serum lipid concentrations in non-hypercholesterolemic adult men and women.(opens in a new tab)
Randomised controlled trial · European journal of nutrition · 2020 · PMID 31388739
- Could dietary seaweed reverse the metabolic syndrome?(opens in a new tab)
Randomised controlled trial · Asia Pacific journal of clinical nutrition · 2009 · PMID 19713172
Deep research mode adds each paper’s own conclusion and stated limitations.