Randomised trials report reductions in depressive symptom scores with standardised saffron extract, typically 30 mg a day, compared with placebo. Reviews consistently flag that the trials are small, short, and overwhelmingly from one region, and the dose is a concentrated extract rather than a culinary pinch, which is a difference of two orders of magnitude.
Moderate evidence. Several human studies point the same way, with real caveats.
2 sources
- Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled Trials.(opens in a new tab)
Meta-analysis · Nutrition reviews · 2025 · PMID 38913392
- Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.(opens in a new tab)
Systematic review · Human psychopharmacology · 2014 · PMID 25384672
Deep research mode adds each paper’s own conclusion and stated limitations.