Digestive comfort
Enteric-coated peppermint oil capsules have been tested in irritable bowel syndrome across a number of randomised trials, and meta-analyses report improvement in global symptoms and abdominal pain compared with placebo. The studied product is a standardised oil capsule taken as a medicine, delivering far more menthol than mint leaves or an infusion, and reviews note that trial quality is uneven.
What may be going on: Menthol blocks calcium channels in intestinal smooth muscle, producing an antispasmodic effect.
Moderate evidence. Several human studies point the same way, with real caveats.
4 sources
- Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome.(opens in a new tab)
Meta-analysis · Alimentary pharmacology & therapeutics · 2022 · PMID 35942669
- Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.(opens in a new tab)
Meta-analysis · Journal of clinical gastroenterology · 2014 · PMID 24100754
- Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis.(opens in a new tab)
Systematic review · The lancet. Gastroenterology & hepatology · 2020 · PMID 31859183
- American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome.(opens in a new tab)
Systematic review · The American journal of gastroenterology · 2018 · PMID 29950604
Deep research mode adds each paper’s own conclusion and stated limitations.