Blood lipid profile
Research consistently shows marine omega-3 oils lowering blood triglycerides, with the effect size scaling with dose and with starting triglyceride concentration. This is one of the most replicated findings in nutrition, supported by many randomised trials and multiple meta-analyses. LDL cholesterol tends to move slightly in the opposite direction, which is part of the same well-characterised picture.
What may be going on: EPA and DHA reduce hepatic very-low-density lipoprotein assembly and secretion and increase fatty acid oxidation in the liver.
Moderate evidence. Several human studies point the same way, with real caveats.
1 source
- Omega-3 fatty acids in parenteral nutrition - A systematic review with network meta-analysis on clinical outcomes.(opens in a new tab)
Systematic review · Clinical nutrition (Edinburgh, Scotland) · 2023 · PMID 36878111
Deep research mode adds each paper’s own conclusion and stated limitations.