Satiety and appetite
Meta-analyses of capsaicin and capsiate trials report small reductions in energy intake at the next meal and a small rise in energy expenditure. The effects are modest, they fade as tolerance develops, and most trials use isolated capsaicinoid capsules rather than a spice blend that is partly salt and oregano.
What may be going on: Capsaicin activates TRPV1 receptors, which triggers a short-lived sympathetic response and appears to influence appetite signalling.
Limited evidence. Early human work, or mostly lab and animal research.
3 sources
- Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence.(opens in a new tab)
Systematic review · Appetite · 2012 · PMID 22634197
- Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data.(opens in a new tab)
Meta-analysis · Appetite · 2014 · PMID 24246368
- The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans.(opens in a new tab)
Meta-analysis · Chemical senses · 2012 · PMID 22038945
Deep research mode adds each paper’s own conclusion and stated limitations.